Pharmacologic modulation of experimentally induced allergic asthma
نویسندگان
چکیده
منابع مشابه
Pharmacologic modulation of experimentally induced allergic asthma
Allergic asthma is the most frequent disease of the respiratory tract. The aim of the current experimental and clinical studies was to find new sources of drugs able to control asthmatic inflammation and airway hyperresponsiveness. Our experimental studies were focused on efficiency evaluation of substances able to influence activities of ion channels, phosphodiesterase (PDE) isoforms, substanc...
متن کاملPharmacologic Treatment of Hyperalgesia Experimentally Induced by Nucleus Pulposus.
OBJECTIVE To evaluate the effect of anti-inflammatory drugs (dexamethasone, indomethacin, atenolol and indomethacin plus atenolol) and analgesic drugs (morphine) on hyperalgesia experimentally induced by the nucleus pulposus (NP) in contact with the L5 dorsal root ganglion (DRG). METHODS Thirty male Wistar rats of weights ranging from 220 to 250 g were used in the study. Hyperalgesia was indu...
متن کاملInduction of experimental allergic asthma in cat
19 cats were nper-sensitized to allergic asthma by receiving a concomitant spray ang injection of ovalbumin (10% fresh egg-white in normal saline) every other days for four weeks.then animals were anesthetized and left femoral artery cannulation performed to record atrerial pressure and take blood samples.left femoral vein was cannulated to infuse nutritional fluids and grugs as needed.trachea ...
متن کاملGeneral overview of fungal allergic asthma
Asthma is a complicated disorder, whose prevalence has increased over the past few decades.Asthma is characterized by infiltration of inflammatory leukocytes along with enhancedproinflammatory cytokines and chemokines. Fungi are now far more widely being considered as thedominant extrinsic trigger for asthma. Fungi are linked to the severity of asthma in many ways. Somedifferences between studi...
متن کامل5-BDBD ameliorates an OVA-induced allergic asthma by the reduction of Th2 cytokines production
Objective(s): P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Materials and Methods: Ovalbumin was used to sensitize and challenge for a mouse model. Intranasal application of 5-BDBD, P2X4R antag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Interdisciplinary Toxicology
سال: 2011
ISSN: 1337-9569,1337-6853
DOI: 10.2478/v10102-011-0006-x